TLR1 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1-4 µg/ml. Detects a band of approximately 90kDa in mouse spleen lysates.  Immunohistochemistry on Frozen Sections: 10 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 16 amino acid peptide located near the amino terminus of Human CD281
Specificity	This antibody detects an epitope within the N-terminal (NT) region of CD281, also known as toll like receptor 1 (TLR1).
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	toll like receptor 1
Database Link	Entrez Gene 7096 Human UniProt ID Q15399
Background	TLRs recognize pathogen associated molecular patterns (PAMPs) that are expressed on infectious agents, and serve as an important link between the innate and adaptive immune response through the production of cytokines. TLR1 is co-expressed with TLR2 on monocytes and dendritic cells where they form heterodimers that can recognize peptidoglycan and bacterial lipopeptides, and in particular triacylated lipoproteins. TLR1 can also regulate other TLR responses; TLR1 can associate with TLR4 and inhibit its signalling in endothelial cells, and can associate with TLR2 to inhibit the TLR2/TLR6 mediated response to phenol-soluble modulin.
Synonyms	Toll-like receptor 1, TIL, KIAA0012
Reference Data

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