LNK (SH2B3) Goat Polyclonal Antibody
CAT#: AP05552PU-N
LNK (SH2B3) goat polyclonal antibody, Purified
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CNY 7,819.00
货期*
4周
规格
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western Blot: 0.3 - 1.0µg/ml; detects a band of approximately 70kDa in human MOLT4 cell lysates. (Predicted Mwt. 63.2kDa) |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide sequence NGPALQPSSPC from LNK amino-terminus. |
Specificity | This antibody recognises an epitope within the N-terminal region (NT) of lymphocyte adaptor protein (LNK). |
Formulation | TRIS buffered saline containing 0.02% Sodium Azide and 0.5% Bovine Serum Albumin State: Purified State: Liquid purified IgG |
Concentration | lot specific |
Purification | Affinity chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Gene Name | SH2B adaptor protein 3 |
Database Link | |
Background | LNK is an SH2-containing adaptor protein, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis. LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFalpha. The role of LNK as a negative regulator, includes the down regulation of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFalpha, modulation of P13-kinase and MAPK ERK1/2 activity, and negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines. |
Synonyms | SH2B3, LNK, SH2B adapter protein 3, Lymphocyte-specific adapter protein Lnk, Signal transduction protein Lnk, Lymphocyte adapter protein |
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