OGR1 (GPR68) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FN, IHC, WB
Recommend Dilution	Western Blot: 5-10 µg/ml. Western blot should be visualized using a high sensitivity secondary/substrate system. Neutralization. Immunohistochemistry. Positive Control: OGR1 transfected cell lysate.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein derived from Human OGR1 (GPR68) protein
Specificity	This antibody recognizes OGR1.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	G protein-coupled receptor 68
Database Link	Entrez Gene 8111 Human UniProt ID Q15743
Background	OGR1 (originally identified as GPR68) is a high-affinity receptor for sphingosylphosphorylcholine (SPC). SPC is a member of a class of bioactive lipids which regulate cellular functions. These functions include cell proliferation and growth inhibition, smooth muscle contration and wound healing. SPC also stimulated signalling pathways that induce tyrosine phosphorylation, activate MAP kinases and protein kinase C, modify ion channel activity and increase intracellular Ca2+ concentration. OGR1 is expressed in placenta, lung, liver, spleen, testis, small intestine and peripheral blood leukocytes. It is not found in thymus, ovary, colon, skeletal muscle, kidney or pancreas.
Synonyms	Sphingosylphosphorylcholine receptor, G-protein coupled receptor 68, GPR12A
Reference Data

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