EDG6 (S1PR4) Rabbit Polyclonal Antibody
CAT#: AP05160PU-N
EDG6 (S1PR4) rabbit polyclonal antibody, Purified
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CNY 9,150.00
货期*
4周
规格
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Specifications
Product Data | |
Applications | WB |
Recommend Dilution | Western Blot: 5 - 10 µg/ml; Detects an approximately 42 kDa band on RH7777 cells transfected with full-length EDG-6. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from the intermediate region of the EDG6 (S1P4) protein. |
Specificity | This antibody reacts to EDG-6 / S1P4 / S1PR4. |
Formulation | Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. |
Gene Name | sphingosine-1-phosphate receptor 4 |
Database Link | |
Background | EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine 1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. |
Synonyms | EDG-6 |
Reference Data |
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