EDG8 (S1PR5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 5 - 10 µg/ml; detects recombinant EDG-8 receptors at 42 kDa; Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Unique synthetic peptide derived from the C-terminus of the human EDG-8 protein
Specificity	This antibody reacts to EDG8.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	sphingosine-1-phosphate receptor 5
Database Link	Entrez Gene 53637 Human UniProt ID Q9H228
Background	Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.
Synonyms	S1P receptor 5, EDG8, SPPR-1, SPPR-2, S1PR5
Reference Data

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