EDG1 (S1PR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 5-10 µg/ml, Detects an approximately 44 kDa band in RH7777 cells transfected with full length human EDG-1. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the C-terminal of the EDG-1 receptor
Specificity	This antibody reacts to EDG1.
Formulation	Phosphate buffered saline with 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	sphingosine-1-phosphate receptor 1
Database Link	Entrez Gene 1901 Human UniProt ID P21453
Background	EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocytecontaining and other tissues.
Synonyms	S1P receptor 1, S1PR1, CHEDG1, EDG1, ECGF1, D1S3362, FLJ58121
Reference Data

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