Dab1 (C-term) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IP, WB
Recommend Dilution	Western Blot: 1 μg/ml. Immunoprecipitation: 5 μg/ml. POSITIVE CONTROL: 293 cells transfected with Dab-1-HA tag.
Reactivity	Mouse
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant protein corresponding to amino acids 399 - 555 of mouse disabled coupled to a GST fusion protein.
Specificity	This antibody reacts to DAB1 (Disabled 1) (C Terminal).
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig (0.2µm sterile filtered)
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	disabled 1
Database Link	Entrez Gene 13131 Mouse UniProt ID P97318
Background	Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.
Synonyms	Disabled homolog 1
Reference Data

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