Eph receptor B1 (EPHB1) (Cytopl. Dom.) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IP
Recommend Dilution	Western Blot: 1 - 10 µg/ml. Immunoprecipitation: 10 - 20 µg/ml.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Immunogen	A GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino
Specificity	This antibody reacts to ephB1 (Elk receptor) - CY.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig (0.2µm sterile filtered)
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	EPH receptor B1
Database Link	Entrez Gene 2047 Human UniProt ID P54762
Background	The immunogen used for the anti-human ephB1 (Elk receptor) - cytoplasmic(CY) region was a GST fusion protein ephB1 (Elk receptor) - CY corresponding to amino acid sequence 586 - 984 of the C terminus region and having a molecular weight of 116 kDa. EphB1, previously known as Elk (eph-like kinase), is a receptor tyrosine kinase of the highly tissue restricted family of eph proteins. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. EphB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. EphB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cell-cell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.
Synonyms	EPHT2, NET, HEK6, ELK, EPH2, Ephrin type-B receptor 1
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways	Axon guidance

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