LMO2 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blots: 1 - 10 µg /ml.
Reactivity	Human
Host	Sheep
Clonality	Polyclonal
Specificity	This antibody reacts to Rhombotin 2.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig (0.2µm sterile filtered)
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	LIM domain only 2
Database Link	Entrez Gene 4005 Human UniProt ID P25791
Background	Two homologues of the rhombotin gene have now been isolated. One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene. Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains. Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus. The Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors. Chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.
Synonyms	LMO2, RBTN2, RBTNL1, RHOM2, TTG2, Rhombotin2, LIM domain only protein 2, Cysteine-rich protein TTG-2, T-cell translocation protein 2
Reference Data

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