Neutrophil Elastase (ELANE) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, R, WB
Recommend Dilution	ELISA (1/8.000). RIA (1/10.000). Western blot (1/500).
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Human purified PMN Elastase
Specificity	This antibody detects Human PMN Elastase. Other species not tested.
Formulation	State: Serum State: Lyophilized serum
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	elastase, neutrophil expressed
Database Link	Entrez Gene 1991 Human UniProt ID P08246
Background	Elastases form a subfamily of serine proteases that hydrolyse many proteins in addition to elastin. Neutrophil elastase (elastase 2) hydrolyses proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia.
Synonyms	ELANE, ELA2, Neutrophil elastase, Elastase-2, PMN elastase, Bone marrow serine protease, Medullasin, Human leukocyte elastase, HLE
Reference Data

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