CGRP (CALCB) Goat Polyclonal Antibody

Specifications

Product Data
Applications	R
Recommend Dilution	RIA (1/3,000).
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Synthetic Human Calcitonin Gene-related Peptide 2, bTG-conjugated
Specificity	This antibody detects Calcitonin Gene-related Peptide. There were no cross reactivities obtained with Human and Salmon Katacalcin and Calcitonin.
Formulation	State: Serum State: Lyophilized serum
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	calcitonin related polypeptide beta
Database Link	Entrez Gene 797 Human UniProt ID P10092
Background	CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
Synonyms	Calcitonin gene-related peptide 2, Beta-type CGRP, CALC2
Note	LocusID: 797
Reference Data

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