MAPT / TAU pThr231 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/500-1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Tau pThr231 protein.
Formulation	Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 50-80 kDa
Gene Name	microtubule associated protein tau
Database Link	Entrez Gene 4137 Human UniProt ID P10636
Background	The Tau family of proteins consists of six isoforms, which become abnormally hyperphosphorylated and accumulate in the form of paired helical filaments in the brains of patients with Alzheimer’s disease. p-Tau can be dephosphorylated by protein phosphatase PP-2B, PP-2A and PP-1, which are all present in neurons. p-Tau is predominately present in neuronal somata and dendrites and, to a lesser extent in axons. PKN specifically phosphorylates Tau to serve as a regulator of microtubules. The phosphorylation state and distribution of Tau can be modulated by insulin and insulin-like growth factor-1 signaling pathways involving glycogen synthase kinase-3β, suggesting that insulin and insulin-growth factor-1 may contribute to the reorganization of the cytoskeleton, which is necessary for the development and growth of the neurites. 14-3-3 ζ can associate with both Tau and p-Tau that stimulates cAMP-dependent kinase to phosphorylate Tau, suggesting that 14-3-3 ζ is a Tau effector that may be involved in the abnormal Tau phosphorylation.
Synonyms	MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau
Reference Data

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