Rb (RB1) pSer807 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Rb pSer807 protein.
Formulation	Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 106 kDa
Gene Name	RB transcriptional corepressor 1
Database Link	Entrez Gene 5925 Human UniProt ID P06400
Background	The genetic predisposition to retinoblastoma is transmitted by mutant alleles of the retinoblastoma susceptibility gene (Rb). Rb encodes a phosphorylated protein of approximately 110 kDa that accumulates in the nuclei of most vertebrate cells, but is lacking in all retinoblastomas examined to date. Mutations in Rb have been found in a wide variety of human tumors. The carboxy terminal domain of Rb p110 binds DNA, although no sequence specificity for this binding has been demonstrated. Inactivation of Rb can be mediated by its binding to the transforming proteins of several DNA tumor viruses, including SV40 T antigen and adenovirus E1A, perhaps accounting for their transforming function. Rb p110 is differentially phosphorylated during the cell cycle, implicating a possible role in cell cycle regulation.
Synonyms	Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
Reference Data

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