p53 (TP53) pSer46 Rabbit Polyclonal Antibody

CAT#: AP01659PU-N

p53 (TP53) pSer46 rabbit polyclonal antibody, Aff - Purified



Need it in bulk or conjugated?
Get a free quote

CNY 4,437.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution Western Blot: 1/500-1/1000.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Specificity p53 antibody detects endogenous levels of p53 pSer46 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 46 kDa
Gene Name tumor protein p53
Background p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD, amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers.
Synonyms Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...