NF-kB p65 (RELA) Rabbit Polyclonal Antibody
CAT#: AP01419PU-N
NF-kB p65 (RELA) rabbit polyclonal antibody, Aff - Purified
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CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot: 1/500-1/1000. |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of NFκB-p65 protein. (region surrounding Lys303) |
Formulation | Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified IgG fraction ( > 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~60 kDa |
Gene Name | RELA proto-oncogene, NF-kB subunit |
Database Link | |
Background | Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NFκB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp κB sequence in the immunoglobulin κ light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFκB is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described, designated p105 and p100. The p105 precursor contains p50 at its amino-terminus and a C-terminal region that when expressed as a separate molecule, designated PDI, binds to p50 and regulates its activity. |
Synonyms | NF kappa B p65, NFkB p65, Transcription factor p65, Rel A, NFKB3 |
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