Inositol Hexakisphosphate Kinase 2 (IP6K2) Rabbit Polyclonal Antibody
CAT#: AP01285PU-N
Inositol Hexakisphosphate Kinase 2 (IP6K2) rabbit polyclonal antibody, Aff - Purified
Size: 25 ul
Need it in bulk or conjugated?
Get a free quote
CNY 1,999.00
CNY 4,640.00
货期*
2周
规格
Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200 Immunohistochemistry on Paraffin sections: 1/500-1/200 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 156-204 of Human IP6K2. |
Specificity | This antibody detects endogenous levels of InsP6 kinase 2 / IP6K2 protein (region surrounding Leu188). |
Formulation | Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15 mM Sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 52 kDa |
Gene Name | inositol hexakisphosphate kinase 2 |
Database Link | |
Background | The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors. |
Synonyms | IHPK2, TCCCIA00113, P(i)-uptake stimulator, PiUS |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...