EMR2 (ADGRE2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western Blot: 1/500-1/1000. Immnofluorescence: 1/50-1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 130-178 of Human EMR2.
Specificity	This antibody detects endogenous levels of EMR2 protein. (region surrounding Leu160)
Formulation	Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 90 kDa
Gene Name	adhesion G protein-coupled receptor E2
Database Link	Entrez Gene 30817 Human UniProt ID Q9UHX3
Background	EMR2 is a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system, where it has been shown to be restricted specifically to monocytes and granulocytes. Family members are characterized by an extended extracellular region with a variable number of N terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms. ESTs have been isolated from blood, colon, lymph node, placenta, spleen, testis, and uterus libraries.
Reference Data

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