Vitronectin (VTN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Native human vitronectin
Specificity	This antibody reacts with both native monomeric and polymeric vitronectin in various tissues and plasma.
Formulation	0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride, 1mM EDTA State: Purified State: Liquid purified Ig
Concentration	lot specific
Purification	>98% pure (SDS-PAGE). Protein A chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody at -70°C. Avoid repeated freezing and thawing.
Gene Name	vitronectin
Database Link	Entrez Gene 7448 Human UniProt ID P04004
Background	Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.
Synonyms	VTN, S-protein, V75
Reference Data

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