LRRK2 (841-960) Mouse Monoclonal Antibody [Clone ID: S231B-34]

Specifications

Product Data
Clone Name	S231B-34
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/100; 10 μg/ml was sufficient for detection of PARK8 / LARRK2 in 20 μg of rat brain lysate by colorimetric immunoblot using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein amino acids 841-960 of human PARK8 / LRRK2. < 30% identity with LRRK1.
Specificity	This antibody detects a > 200 kDa protein corresponding to the molecular weight of PARK8 / LARRK2.
Formulation	PBS pH 7.4, 50% Glycerol, 0,09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	leucine-rich repeat kinase 2
Database Link	Entrez Gene 120892 Human UniProt ID Q5S007
Background	PARK8 / LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
Synonyms	Dardarin
Reference Data

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