FGF13 (N-term) Mouse Monoclonal Antibody [Clone ID: S235-22]

Specifications

Product Data
Clone Name	S235-22
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/1000; 1μg/ml was sufficient for detection of FGF13 (pan) in 20 μg of rat brain lysate by colorimetric immunoblot using HRP conjugated secondary antibody. Immunocytochemistry. Immunohistochemistry: Free floating sections, fixed in formaldehyde.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide amino acids 2-18 of human FGF13 protein.
Specificity	This antibody detects a 30 kDa protein. Does not cross-react with FGF13B/FHF2B. Cross reacts with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A (80% sequence identity).
Formulation	PBS pH 7.4, 50% Glycerol, 0,09% Sodium azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Protein G chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	fibroblast growth factor 13
Database Link	Entrez Gene 2258 Human UniProt ID Q92913
Background	FGF13 (Fibroblast growth factor 13), also called FHF2 is a protein that in humans is encoded by the FGF13 gene.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF13is a large gene, extending over approximately 200 kb in Xq26.3, and contains at least 7 exons. By cytogenetic, FISH, and database analysis, Gecz et al. (1999) localized the FGF13 gene within a 400-kb duplication interval on chromosome Xq26.3. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located to a region associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a syndromal X-linked mental retardation, which suggests it may be a candidate gene for familial cases of the BFL syndrome. The function of this gene has not yet been determined. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Synonyms	FGF-13, FHF2, Fibroblast growth factor 13, Fibroblast growth factor homologous factor 2, FGFA, FHFA
Reference Data

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