NUDT1 Mouse Monoclonal Antibody [Clone ID: AT3B3]

Specifications

Product Data
Clone Name	AT3B3
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human NUDT1 (1-156aa) purified from E. coli.
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	nudix hydrolase 1
Database Link	Entrez Gene 4521 Human UniProt ID P36639
Background	NUDT1, also known as MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, NUDT1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, NUDT1 prevents misincorporation of GTP into D, thus preventing A:T to C:G transversions.
Synonyms	7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, MTH1
Reference Data
Protein Families	Stem cell - Pluripotency

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