Glutathione Reductase (GSR) Mouse Monoclonal Antibody [Clone ID: AT11D10]

Specifications

Product Data
Clone Name	AT11D10
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human GSR (43-522aa) purified from E.coli.
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glutathione reductase
Database Link	Entrez Gene 2936 Human UniProt ID P00390
Background	Glutathione reductase(GR) also known as glutathione-disulfide reductase(GSR) is an enzyme that in humans is encoded by the GSR gene. Glutathione reductase catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form glutathione(GSH), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell. Glutathione reductase functions as dimeric disulfide oxidoreductase and utilizes an FAD prosthetic group and NADPH to reduce one mole of GSSG to two moles of GSH.
Synonyms	GRase, GR, GSR, GLUR, GRD1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism

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