PARP2 Mouse Monoclonal Antibody [Clone ID: AT29G4]

Specifications

Product Data
Clone Name	AT29G4
Applications	ELISA, FC, IF, WB
Recommend Dilution	ELISA. Flow Cytometry Immunocytochemistry/Immunofluorescence. Western blot / Immunoblot. The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:5000. Recommended starting dilution is 1:500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PARP2 (233-583aa) purified from E. coli
Formulation	PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	poly(ADP-ribose) polymerase 2
Database Link	Entrez Gene 10038 Human UniProt ID Q9UGN5
Background	PARP2 is poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
Synonyms	PARP-2, ADPRT2, ADPRTL2, Poly [ADP-ribose] polymerase 2, PARP 2, EC=2.4.2.30, pADPRT-2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Base excision repair

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