Cd5 Mouse Monoclonal Antibody [Clone ID: HIS47]

Specifications

Product Data
Clone Name	HIS47
Applications	IF, IHC
Recommend Dilution	Flow cytometry. Immunofluorescence. Immunohistochemistry on frozen sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody recognizes peripheral T lymphocytes and thymocytes (CD5). In rats, a CD5+ subset of B lymphocytes has not beem characterized.
Formulation	State: Supernatant State: Liquid cell culture supernatant containing 0.09% sodium azide
Conjugation	Unconjugated
Storage Condition	Store undiluted a 2-8°C.
Gene Name	Cd5 molecule
Database Link	Entrez Gene 54236 Rat UniProt ID P51882
Background	CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, (human) subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD72 is the major ligand for CD5.
Synonyms	CD5, LEU1
Reference Data

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