c-Myc (MYC) Mouse Monoclonal Antibody [Clone ID: MYC699]

CAT#: AM33353PU-T

c-Myc (MYC) mouse monoclonal antibody, clone MYC699, Purified

Size: 20 ug 100 ug



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CNY 3,223.00


货期*
5周

规格
    • 20 ug

Product images

Specifications

Product Data
Clone Name MYC699
Applications FC, IF, IHC, IP, WB
Recommend Dilution ELISA: Use BSA free Antibody for coating.
Flow Cytometry: 0.5-1 μg/million cells.
Immunofluorescence: 1-2 μg/ml.
Western Blotting: 0.5-1 μg/ml.
Immunoprecipitation: 1-2 μg/500 μg protein lysate.
Immunohistochemistry on Frozen Sections: 0.5-1.0 μg/ml for 30 minutes at RT.
Positive Control: HL-60 cells or breast carcinoma.
Reactivity Chimpanzee, Human, Gorilla
Host Mouse
Clonality Monoclonal
Immunogen A synthetic peptide, corresponding to aa 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQL-RNSCA) from C-terminus of Human c-myc, coupled to KLH.
Specificity Recognizes c-Myc Oncoprotein.
Cellular Localization: Nuclear.
Formulation 10mM PBS
State: Purified
State: Liquid purified IgG fraction from Bioreactor Concentrate
Stabilizer: 0.05% BSA
Preservative: 0.05% Sodium Azide
Concentration lot specific
Purification Protein A/G Chromatography
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
Predicted Protein Size 62-64 kDa
Gene Name v-myc avian myelocytomatosis viral oncogene homolog
Background The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiatio n, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/ Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase ( JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c -Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribut e blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
Synonyms Transcription factor p64, BHLHE39
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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