DGKA (C-term) Mouse Monoclonal Antibody [Clone ID: M8]

Specifications

Product Data
Clone Name	M8
Applications	IP, WB
Recommend Dilution	Western blot. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Escherichia coli cell-expressed, affinity-purified Glutathione S-transferase fusion protein of a C-terminal portion (part of the catalytic domain) of Rat DGKu.
Specificity	This Monoclonal M8 Antibody is directed against the C-terminal portion (part of the catalytic domain) of Rat DGK alpha.
Formulation	PBS State: Purified State: Liquid purified fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	diacylglycerol kinase alpha
Database Link	Entrez Gene 1606 Human UniProt ID P23743
Background	Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. Tissue specificity: lymphocytes and oligodendroglial cells. Diacylglycerol kinases are involved in cell signaling, either as regulators of diacylglycerol levels or as intracellular signal-generating enzymes.
Synonyms	Diacylglycerol kinase alpha, Diglyceride kinase alpha, DGKA, DAGK, DAGK1, DGK-alpha
Reference Data

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