PTP rho (PTPRT) Mouse Monoclonal Antibody [Clone ID: 3D7]

Specifications

Product Data
Clone Name	3D7
Applications	FC, IF, IP, WB
Recommend Dilution	Western blot. Immunoprecipitation. Immunofluorescence. Flow Cytometry.
Reactivity	Human, Porcine, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody has been derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads. The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPµ molecule (aa 1-742), fused COOH terminally to GST.
Specificity	Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPµ.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type T
Database Link	Entrez Gene 11122 Human UniProt ID O14522
Background	Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPµ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions. Intracellularly, RPTPµ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPµ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPµ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Synonyms	PTP rho, RPTP-rho, R-PTP-T, KIAA0283
Reference Data

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