EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: 214D4]

Specifications

Product Data
Clone Name	214D4
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections (10 µg/ml).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a fusion protein, Human beta-Gal-Episialin/MUC1 repeat domain.
Specificity	This Monoclonal 214D4 antibody is directed against the repeat domain of Episialin.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Gene Name	mucin 1, cell surface associated
Database Link	Entrez Gene 4582 Human UniProt ID P15941
Background	Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
Synonyms	MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data

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