Drebrin (DBN1) (1-326) Mouse Monoclonal Antibody [Clone ID: DBN-N-03]

Specifications

Product Data
Clone Name	DBN-N-03
Applications	FC, WB
Recommend Dilution	Flow Cytometry. Western Blot. Positive Control: REH, Nalm-6, HEK293 cells.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Specificity	This Monoclonal antibody DBN-N-03 recognizes Drebrin, an approximately 100-125 kDa regulator of actin cytoskeleton.
Formulation	Tris buffered saline (TBS), pH~8.0 State: Purified State: Liquid purified IgG fraction (> 95% by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	drebrin 1
Database Link	Entrez Gene 1627 Human UniProt ID Q16643
Background	Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.
Synonyms	DBN1, DBN-1, D0S117E, DKFZp434D064,drebrin 1
Reference Data

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