HLA Class II DR Mouse Monoclonal Antibody [Clone ID: B-C10]
CAT#: AM32426PU-N
HLA Class II DR mouse monoclonal antibody, clone B-C10, Purified
Conjugation: FITC
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CNY 3,350.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | B-C10 |
Applications | FC |
Recommend Dilution | Flow Cytometry: Use 10 µl of 106 cells or 100 µl of whole blood. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | RPMI 8866 and DAUDI cell lines. Myeloma X63/AG.8653 x Balb/c spleen cells. |
Specificity | This Monoclonal antibody recognises the HLA Class II (DR) membrane. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide |
Purification | Ion Exchange Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Background | Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II alpha/beta dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles. |
Synonyms | HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR |
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