CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: 3B8 2A1]

Specifications

Product Data
Clone Name	3B8 2A1
Applications	ELISA, IHC, IP, WB
Recommend Dilution	ELISA. Flow Cytometry. Immunoassay. Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections. The typical starting working dilution is 1/10.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody reacts to Transferrin Receptor 1.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 0,1% BSA Preservative: 0.02% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	transferrin receptor
Database Link	Entrez Gene 7037 Human UniProt ID P02786
Background	Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2.
Synonyms	TfR1, p90, Transferrin receptor protein 1
Reference Data

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