c Kit (KIT) (C-term) Rabbit Monoclonal Antibody [Clone ID: YR145]
CAT#: AM32271SU-N
c Kit (KIT) (C-term) rabbit monoclonal antibody, clone YR145, Supernatant
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CNY 17,306.00
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Specifications
Product Data | |
Clone Name | YR145 |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on frozen and paraffin sections: 1/25 - 1/100. Preparation and Pretreatment: 1. Cut 3-4 μm section of formalin-fixed paraffin-embedded tissue and place on positively charged slides; dry overnight at 58°C. 2. Deparaffinize, rehydrate, and epitope retrieve; the preferred method is the use of Heat Induced Epitope Retrieval (HIER) techniques in conjunction with a pressure cooker. The preferred method allows for simultaneous deparaffinization, rehydration, and epitope retrieval. Upon completion, rinse with 5 changes of distilled or deionized water. 3. If using HRP detection system, place slides in peroxide block for 10 minutes; rinse. If using AP detection system, omit this step. Positive control: Breast, GIST, Skin, Testes Staining pattern: Cytoplasmic, Membranous |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Specificity | This antibody reacts to CD117. |
Formulation | PBS, pH 7.4 State: Supernatant State: Liquid supernatant Stabilizer: 0,9% BSA Preservative: 0,09% sodium azide |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. |
Gene Name | KIT proto-oncogene receptor tyrosine kinase |
Database Link | |
Background | CD117, c-kit is a tyrosine kinase receptor found on interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells. This receptor is found on a wide variety of tumor cells (follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, breast; malignant melanoma, endodermal sinus tumor, and small cell carcinoma) but has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi’s sarcoma, and tumors of smooth muscle origin. |
Synonyms | SCFR, KIT |
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