EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: VU-2G7]

Specifications

Product Data
Clone Name	VU-2G7
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on frozen and paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A Balb/c mouse was immunized with synthetically glycosylated MUC1 60mer tandem repeat NH2-(HGVTSAPDT(GalNAc)RPAPGSTAPPAHG)3-COOH, conjugated to bovine serum albumin. Splenocytes were fused with SP2/0 mouse myeloma cells.
Specificity	This antibody reacts to MUC1.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0,05% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mucin 1, cell surface associated
Database Link	Entrez Gene 4582 Human UniProt ID P15941
Background	VU-2G7 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 aminoacids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of VU-2G7 has not been established with “epitope fingerprinting”.
Synonyms	MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3
Reference Data

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