Integrin beta 1 (ITGB1) Mouse Monoclonal Antibody [Clone ID: DF5]

Specifications

Product Data
Clone Name	DF5
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting: 1/1000. Immunohistochemistry on Frozen Sections Immunohistochemistry on Paraffin Sections (See Bernardini N. et al. 1997). Other Immunoassays for cellular and tumor biology.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Wheat germ agglutinin binding glycoproteins of Human fibroblasts. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody reacts with the beta-1 subunit of the Integrin protein family and seems to be Human specific. It reacts with an extracellular epitope of the beta-1 integrin molecule.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 1.0% (w/v) BSA Preservative: 0.09% (w/v) Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit beta 1
Database Link	Entrez Gene 3688 Human UniProt ID P05556
Background	CD29 or the integrin beta-1 belongs to the family of cell adhesion receptors. It was initially characterized independently as protein gpIIa appearing on platelets, as the common beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. The CD29 is expressed at the cell surface exclusively as part of a heterodimer, in association with one of at least nine different integrin alpha subunits (alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, alpha 6, alpha 7, alpha 8, and alpha v). With the exception of red blood cells and possible weak expression on granulocytes, CD29 is expressed nearly all cell and tissue types. Monoclonal antibodies against this β1-Integrin subunit are applicable in paraffin-embedded and frozen sections, immunoblotting and immunoprecipitation. Numerous studies have shown that β1 -Integrins have a distinct and wide cellular distribution and that there are alterations in malignant cells in their beta-1 integrin expression.
Synonyms	Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta, ITGB1, FNRB, MDF2, MSK12
Reference Data

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