Vinculin (VCL) Mouse Monoclonal Antibody [Clone ID: FB11]

Specifications

Product Data
Clone Name	FB11
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting: Use at least 1/1000.  Immunohistochemistry on Frozen Sections. Immunoassays for cellular and tumor biology.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Vinculin from Human smooth muscle. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody reacts with the Vinculin antigen. In Immunoblotting the antibody identifies a 130 kD polypeptide.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 1% BSA Preservative: 0.09% Sodium Azdie
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	vinculin
Database Link	Entrez Gene 7414 Human UniProt ID P18206
Background	Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and alpha actinin, which in turn binds to actin. The binding of fibronectin is also indirect where vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor which itself is the ligand for fibronectin. Vinculin is widely distributed in tissue and is expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix.
Synonyms	Metavinculin
Reference Data

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