ACTH (POMC) Mouse Monoclonal Antibody [Clone ID: 57]

Specifications

Product Data
Clone Name	57
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Formalin Fixed Paraffin Sections: 1/100-1/200. Protein digestion pretreatment of paraffin sections e.g. trypsin or pronase is required.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Keyhole Limpet Haemocyanin conjugated Human ACTH (1-17)
Specificity	Specific for Synacthen (1-24 ACTH). Reacts with ACTH (a.a. 1-17) and does not cross-react with CLIP (ACTH 17-39). It cross-reacts with Rat N-terminal ACTH.
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	proopiomelanocortin
Database Link	Entrez Gene 5443 Human UniProt ID P01189
Background	ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.
Synonyms	Corticotropin, Adrenocorticotropic hormone, POMC
Reference Data

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