CD56 Mouse Monoclonal Antibody [Clone ID: NKI-nbl-1]

Specifications

Product Data
Clone Name	NKI-nbl-1
Applications	IF, IHC, IP
Recommend Dilution	Immunofluorescence. Immunoprecipitation. Immunohistochemistry on Frozen Sections. The antibody is further useful for studies on neoplasms of the lung and the nervous system.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Neuroblastoma cell line CHP-212.
Specificity	The antibody clone NKI-nbl-1 recognizes a heterodimeric glycoprotein of 145, 185 kD which has been identified as NCAM (Neural Cell Adhesion Module). Two major epitopes have been defined, clone NKI-nbl-1 (Cat.-No AM32056) reacts with epitope 1 and clone 123C3 (Cat.-NoAM05639PU-N) reacts with epitope 2.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	neural cell adhesion molecule 1
Database Link	Entrez Gene 4684 Human UniProt ID P13591
Background	NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.
Synonyms	NCAM-1, N-CAM-1, NCAM
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Prion diseases

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