TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: T3]

Specifications

Product Data
Clone Name	T3
Applications	IP, WB
Recommend Dilution	Western blotting: Use 1/10 as a starting dilution.  Flow Cytometry:  Use 1/10 as a starting dilution.  Immuno Assays.  Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody reacts with free soluble (17 kDa) and membrane (26 kDa) Human TNF-alpha. The antibody inhibits the biological activity of soluble and membrane TNF-alpha.  The antibody can be a useful tool to discriminate between receptor bound soluble (17 kDa) and the membrane (26 kDa) form of TNF-alpha. For this purpose we recommend to use this antibody in combination with the anti-TNF-alpha antibody Cat.-No AM32017 clone T1, which recognizes only soluble and membrane TNF-alpha, but not the receptor bound TNF-alpha.
Formulation	Label: Biotin State: Purified State: Liquid (0.2 μm filtered) Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	tumor necrosis factor
Database Link	Entrez Gene 7124 Human UniProt ID P01375
Background	Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis, and viral replication. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases, as well as cancer.
Synonyms	TNF, TNF-a, TNFA, TNFSF2, Cachectin
Reference Data

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