ABCC12 Rat Monoclonal Antibody [Clone ID: M9II-3]

Specifications

Product Data
Clone Name	M9II-3
Applications	IF, IHC, WB
Recommend Dilution	Western blotting: Use at 1/20-1/50 and anti-Rat-HRP. Immunocytochemistry: Use at 1/20-1/50 on Acetone Fixed Cytospin preparations. Immunohistochemisty on Frozen Sections: 1/20 on Acetone Fixed Frozen sections can be followed by incubation with Rabbit anti-Rat Ig (1/25) and a monoclonal Rat APAAP complex (1/50). Alternatively, after incubation with M9II-3 (use 1/20) and washing, slides can be incubated with biotinylated Rabbit anti-Rat Ig (1/100) and streptavidin conjugated to Horseradish Peroxidase (1/500).
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Immunogen	A bacterial fusion protein of Human MRP9, containing amino acids 690-734 of the protein.
Specificity	This Monoclonal antibody M9II-3 reacts with an internal epitope of MRP9 (ABCC12), an approximately 150 kD transmembrane protein that is related to the multidrug resistance protein MRP1.
Formulation	State: Supernatant State: Serum Free Culture Supernatant Stabilizer: 0.7% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store antibody undiluted at 2-8°C.
Gene Name	ATP binding cassette subfamily C member 12
Database Link	Entrez Gene 94160 Human UniProt ID Q96J65
Background	This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
Synonyms	Multidrug resistance-associated protein 9
Reference Data

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