Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-A35]

Specifications

Product Data
Clone Name	B-A35
Applications	FC
Recommend Dilution	Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TF1 cell line.
Specificity	Recognises the soluble antigen. Recognises Thrombomodulin (TM), a 105 kDa protein.
Formulation	PBS, Sterile-filtered through 0.22 µm, Carrier and preservative free State: Azide Free State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	thrombomodulin
Database Link	Entrez Gene 7056 Human UniProt ID P07204
Background	CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
Synonyms	Thrombomodulin, THRM, Fetomodulin
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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