IL6 Mouse Monoclonal Antibody [Clone ID: B-E8]

Specifications

Product Data
Clone Name	B-E8
Applications	ELISA, FC, FN
Recommend Dilution	ELISA. Flow Cytometry (Intra-cytoplasmic). Fuctional Assay: Blocks IL-6 induced proliferation on B9 cells. Inhibits IL-6 binding to its receptor.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant IL-6.
Specificity	Recognises both natural and recombinant Human IL-6
Formulation	PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 6
Database Link	Entrez Gene 3569 Human UniProt ID P05231
Background	Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
Synonyms	IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.