IL31 Mouse Monoclonal Antibody [Clone ID: B-S31]

Specifications

Product Data
Clone Name	B-S31
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human IL-31
Specificity	This antibody recognises both natural and recombinant IL-31.
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free State: Azide Free State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ion exchange chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 31
Database Link	Entrez Gene 386653 Human UniProt ID Q6EBC2
Background	Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Synonyms	IL-31
Reference Data
Protein Families	Secreted Protein, Transmembrane

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