MICA Mouse Monoclonal Antibody [Clone ID: B-N31]

Specifications

Product Data
Clone Name	B-N31
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human MICA
Specificity	This antibody recognises both natural and recombinant MICA.
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free State: Azide Free State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	MHC class I polypeptide-related sequence A
Database Link	Entrez Gene 100507436 Human UniProt ID Q29983
Background	The MHC class I chain-related (MIC) proteins are related to the Major histocompatibility complex (MHC) class I proteins which are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. The MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote antitumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. MICA is present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system. MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
Synonyms	MHC class I polypeptide-related sequence A, MIC-A, PERB11.1
Reference Data

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