SGK1 Mouse Monoclonal Antibody [Clone ID: 3G8]

Specifications

Product Data
Clone Name	3G8
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA. Immunofluorescence: 10 µg/ml. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	SGK (AAH01263, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity	This antibody recognizes SGK1.
Formulation	PBS, pH 7.2 State: Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Protein A chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	serum/glucocorticoid regulated kinase 1
Database Link	Entrez Gene 6446 Human UniProt ID O00141
Background	SGK, a SGK type protein kinase, is a multi-functional kinase that is phosphorylated and activated through a 3-phosphoinositide-dependent protein kinase 1 (PDK1) signaling pathway. The protein has been shown to activate certain potassium, sodium and chloride channels which function in cell survival, neuronal excitability and renal sodium excretion. SGK transcription can be stimulated by glucocorticoids, aldosterone, TGF-beta1, serum, increase of intracellular Ca2+ and phorbolesters, and can be downregulated by cAMP. At least 2 mRNA variants have been reported. The SGK1 gene has been mapped to chromosome 6q23, a region frequently affected by deletion in various human neoplasms, and has been shown to be upregulated in lung fibrosis, diabetic nephropathy and chronic viral hepatitis.
Synonyms	Serine/threonine-protein kinase Sgk1
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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