VE Cadherin (CDH5) Mouse Monoclonal Antibody [Clone ID: 55-7H1]

Specifications

Product Data
Clone Name	55-7H1
Applications	IF
Recommend Dilution	Flow Cytometry. Immunoprecipitation. Western blot. Immunohistochemistry (frozen sections). Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human endothelial cells
Specificity	This antiibody recognizes a calcium-independent epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells.
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	cadherin 5
Database Link	Entrez Gene 1003 Human UniProt ID P33151
Background	CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.
Synonyms	VE-Cadherin, Vascular endothelial cadherin, CDH5
Reference Data

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