DLL4 Mouse Monoclonal Antibody [Clone ID: MHD4-46]

Specifications

Product Data
Clone Name	MHD4-46
Applications	FC, FN
Recommend Dilution	Flow cytometry. Functional application: blocking.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant soluble human DLL4
Specificity	This antibody recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Formulation	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. State: Low Endotoxin State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	delta like canonical Notch ligand 4
Database Link	Entrez Gene 54567 Human UniProt ID Q9NR61
Background	DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Synonyms	Delta 4, Drosophila Delta homolog 4
Reference Data

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