TNFSF12-TNFSF13 Mouse Monoclonal Antibody [Clone ID: CARL-1]

Specifications

Product Data
Clone Name	CARL-1
Applications	FC, FN
Recommend Dilution	Flow cytometry. Functional application: Neutralization.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CD255-transfected 2PK-3 cells
Specificity	This antibody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.
Formulation	Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide. State: Low Endotoxin State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	TNFSF12-TNFSF13 readthrough
Database Link	Entrez Gene 407977 Human UniProt ID O43508
Background	CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
Synonyms	APO3 ligand, APO3L, DR3LG
Reference Data

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