CD160 Mouse Monoclonal Antibody [Clone ID: BY55]

Specifications

Product Data
Clone Name	BY55
Applications	FC, IP
Recommend Dilution	Flow cytometry. Immunoprecipitation.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human NK cell line YT2C2
Specificity	This antibody recognizes CD160, a 27 kDa glycoprotein expressed on NK cells, NK-T cells, intestinal intraepithelial lymphocytes, TCR-gamma/delta T cells and a small population of TCR-alpha/beta T cells. The antibody detects both GPI-anchored and transmembrane form of CD160.
Formulation	Tris buffered saline (TBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 8.0
Concentration	lot specific
Purification	Ion exchange chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD160 molecule
Database Link	Entrez Gene 11126 Human UniProt ID O95971
Background	CD160 is a cell surface glycoprotein of immunoglobulin superfamily, which functions as a costimulatory receptor expressed mainly on cytotoxic cell populations and recognizing both classical and non-classical MHC class I molecules. It can form disulfide-linked multimers. Down-modulation of CD160 occurs as a consequence of its proteolytic cleavage and the released soluble form was found to impair the MHC-class I specific cytotoxicity of CD8+ T lymphocytes and NK cells. In contrast to GPI-anchored isoform with broader expression among CD160 positive cells, expression of the transmembrane isoform is restricted to NK cells and is activation-dependent.
Synonyms	BY55
Reference Data

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