CBX3 Mouse Monoclonal Antibody [Clone ID: 2MOD-1G6]

Specifications

Product Data
Clone Name	2MOD-1G6
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin sections: 0.4 µg/ml (1/500). Suggested positive control: Human / Porcine brain cortex.
Reactivity	Human, Mouse, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant mouse HP1γ
Specificity	This antibody detects HP1γ.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized purified Ig fraction Stabilizer: 5 mg/ml bovine serum albumin (BSA) Preservative: 0.01 % Kathon
Reconstitution Method	Reconstitute by adding 0.5 ml distilled water. This stock solution contains 0.2 mg/ml IgG.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Database Link	UniProt ID P23198
Background	Heterochromatin Protein 1 (HP1) ("Chromobox Homolog", CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functi ons in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C-terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post-translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.
Synonyms	Chromobox protein homolog 3, HECH, HP1 gamma, HP1-gamma, HP1Hs-gamma
Reference Data

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