alpha Synuclein (SNCA) (1-140) Mouse Monoclonal Antibody [Clone ID: 4H11]

Specifications

Product Data
Clone Name	4H11
Applications	WB
Recommend Dilution	Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human α-synuclein (1-140 aa) expressed in E. coli
Specificity	This antibody recognizes the recombinant α-synuclein
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized purified Ig fraction
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20 °C. Avoid repeated freezing and thawing.
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	Alpha-Synuclein belongs to a family of small cytoplasmic proteins expressed predominantly in neurons. Alpha-synuclein may be involved in neuronal plasticity and could act as a molecular chaperone that mediates the transformation of soluble Aβ into insoluble amyloid. The protein is a major component of Lewy bodies, the pathological hallmark of Parkinson’s disease, and is also observed in senile plaques of Alzheimer’s disease patients. Human α-synuclein appears to be phosphorylated at two major sites, serine 129 and serine 87, and phosphorylation may play a role in the functional regulation of the protein.
Synonyms	NACP, PARK1
Reference Data

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